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copertina di Pancreatic Cancer

Pancreatic Cancer

di Neoptolemos - Urrutia - Abbruzzese - Büchler  • 2009  • dettagli prodotto

spedizione gratuita
normalmente disponibile
per la spedizione in 10-15 giorni lavorativi


Worldwide, there are an estimated 232, 000 new cases of pancreatic cancer annually. In the United States, it is the fourth leading cause of cancer death, and approximately 30,000 people die of pancreatic cancer each year. The disease is difficult to diagnose in its early stages, and most patients have incurable disease by the time they present with symptoms. The overall 5-year survival rate for this disease is less than 5%. In organizing this handbook, Dr. Neoptolemos and his co-editors will produce a distinguished Major Reference Work devoted to pancreatic cancer. This handbook will have widespread appeal among clinicians, pathologists and basic scientists who are now struggling to understand this complex and rapidly expanding field.Because of the recent and vast growth in both the clinical and scientific research being done in pancreatic cancer (there is currently an unprecedented investment by academia and industry in this field), each researcher’s knowledge of other specialty areas outside his or her own is now often quite limited. The aim of this book is to place these the tangible advances—those that are indispensable to all working on pancreatic cancer—readily at hand. The book will focus on advances that will not become dated, and the editors will choose authors who are the very best in each area.Table of contents The Nature of Pancreatic Cancer1.Epidemiology: world overview, risk factors, prospects for prevention2.Development and structure of pancreas3.Pathologic classification and biological behaviour of pancreatic neoplasia4.Developmental molecular biology of the pancreas5.Molecular pathology of precursor lesions of pancreatic cancer, pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), and mucinous cystic neoplasm (MCN)6.Epigenetics: its fundamentals and applications to a revised comprehensive progression model for pancreatic cancer7.Molecular pathology of pancreatic neuroendocrine tumours MEN-1: gastrinomas, insuloma, Non-Functioning Tumours, VIPoma, glucagonoma, Von Hippel-Lindau, Neurofibromatosis8.Sporadic neuroendocrine pancreatic tumours9.Molecular pathology of non-pancreatic cancer lesions: Ampullary cancer, intra-pancreatic bile duct cancer, and duodenal cancer10.Miscellaneous non-pancreatic non-endocrine tumours11.Novel molecular relationships between chronic pancreatitis and cancer12.Pancreatic cancer stem cells13.Cell cycle control: signalling pathways in pancreatic pathogenesis14.Apoptosis: signalling pathways in pancreatic pathogenesis15.EGFR: signalling pathways in pancreatic pathogenesis Pl3, Akt, lKK, Ras, Raf, MAPKK, ERK 16.Hedgehog: signalling pathways in pancreatic pathogenesis17.Smad4/TGF-ß pathway: signalling pathways in pancreatic pathogenesis18.Notch signalling in pancreatic morphogenesis and pancreatic cancer19.Molecular characterization of pancreatic cell lines20.Mouse models of exocrine pancreatic cancer 21.Principles and applications of microarray gene expression in pancreatic cancer22.Principles and applications of proteomics in pancreatic cancer 23.Tumour-stromal interaction: invasion and metastases24.Genetic susceptibility, high risk groups, chronic and hereditary pancreatitis, familial pancreatic cancer syndromes25.Inherited endocrine pancreatic tumors associated with Multiple Endocrine Neoplasia Type 1 Von-Hippel-Lindau Syndrome, and Neurofibromatosis Type 1Section Two: Clinical Management of Pancreatic Cancer26.Clinical decision making in pancreatic cancer27.Paraneoplastic syndromes28.Diagnostic and therapeutic response markers29.CT and fusion PET-CT Diagnosis, staging, and follow-up30.MRI and MRCP: diagnosis and staging of pancreatic cancer31.EUS Diagnosis and staging32.Laparoscopy and laparoscopic ultrasound: diagnosis and staging33.Overview of palliative management for pancreatic cancer34.Endoscopy.35.Interventional radiology 36.Role of palliative surgery in advanced pancreatic cancer37.Chemotherapy for advanced pancreatic cancer 38.Developments in chemoradiation in advanced pancreatic cancer39.Surgical resection for pancreatic cancer 40.Role of venous resection in pancreatic cancer surgery41.Pathological reporting and staging following resection42.Japanese Pancreas Society staging for pancreatic cancer43.Adjuvant chemotherapy in pancreatic cancer44.Case for adjuvant chemoradiation therapy for pancreatic cancer45.Case for neoadjuvant treatment in pancreatic cancer46.Borderline resectable disease47.Management of cystic neoplasms serous cystic neoplasms mucinous, cystic neoplasms, intraductal paillary mucinous neoplasms48.Laparoscopic surgery for pancreatic neoplasm49.Modern Japanese approach to pancreas cancerSection Three: New Directions50.Development of novel biomarkers51.Inherited genetics of pancreatic cancer and secondary screening52.Gene therapy for pancreatic cancer53.Vaccine therapy and immunotherapy54.Emerging targets in pancreatic cancer


ISBN: 0387774971

Titolo: Pancreatic Cancer


Editore: Springer Verlag

Volume: Opera in due volumi

Edizione: 2009

Lingua: Inglese

Finitura: Copertina rigida

Pagine: 1000