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Phagocytosis of Dying Cells - From Molecular Mechanisms to Human Diseases

di Krysko - Vandenabeele  • 2009  • dettagli prodotto

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This comprehensive volume integrates the most innovative and current findings from several related disciplines of scientific research, including pathology, immunology, genetics, and cellular and molecular biology. It is divided into two sections: “Molecular mechanisms of phagocytosis of dying cells” and “Impairment of phagocytosis of dying cells and its role in the development of diseases”. No other recent books devoted to this subject are available.All of the contributors are experts working at the forefront of scientific discovery, and the reviews they present systematically examine the most exciting and innovative aspects of their particular areas of expertise. Both researchers and physicians will find this volume of major benefit because it covers the immunological and molecular biological aspects of phagocytosis of dying cells as well as its clinical relevance.Table of contents Part I. Molecular mechanisms of phagocytosis of dying cellsChapter 1. Molecular pathways of different types of cell death: many roads to death, Dmitri V. Krysko, Agnieszka Kaczmarek and Peter VandenabeeleChapter 2. Apoptotic, necrotic and autophagic cell death types in pathophysiological conditions: morphological and histological aspects, Araceli Diez-Fraile, Tim Lammens and Katharina D’HerdeChapter 3. Role of attraction and danger signals in the uptake of apoptotic and necrotic cells and its immunological outcome, Christoph Peter, Sebastian Wesselborg, Kirsten LauberChapter 4. Molecules involved in recognition and clearance of apoptotic/necrotic cells and cell debris, Markus Napirei and Hans Georg MannherzChapter 5. Evolutionarily conserved pathways regulating engulfment of apoptotic cells, Matthew A. Gronski and Kodi S. RavichandranChapter 6. Innate apoptotic immunity: a potent immunosuppressive response repertoire elicited by specific apoptotic cell recognition, David S. UckerChapter 7. Comparative characterization of non-professional and professional phagocyte responses to apoptotic cells, Adam Lacy-HulbertChapter 8. Methods used to study apoptotic cell clearance, Uriel Trahtemberg and Dror MevorachPart II. Impairment of phagocytosis of dying cells and its role in the development of diseases Chapter 9. Results of defective clearance of apoptotic cells: lessons from knockout mouse models, Christopher D Gregory and John D PoundChapter 10. Clearance of dying cells and systemic lupus erythematosus, Dror MevorachChapter 11. Apoptotic cells for therapy of transplant rejection, Sherrie J. Divito and Adrian E. MorelliChapter 12. Impact of tumor cell death on the activation of anti-tumor immune response, Jirina Bartunková and Radek ≤pí∫ekChapter 13. Phagocytosis of dying cells in the pathogenesis of atherosclerosis, Wim Martinet, Dorien M Schrijvers, Guido RY De MeyerChapter 14. The impact of defective clearance of apoptotic cells in the pathogenesis of chronic lung diseases: chronic obstructive pulmonary disease, asthma and cystic fibrosis, Paul N. Reynolds and Sandra J. HodgeChapter 15. Environmental factors affecting phagocytosis of dying cells: smoking and static magnetic fields, Luciana Dini and Cristian VergalloIndex


ISBN: 140209292X

Titolo: Phagocytosis of Dying Cells - From Molecular Mechanisms to Human Diseases


Editore: Springer Verlag

Volume: Unico

Edizione: 2009

Lingua: Inglese

Finitura: Copertina rigida