This book deals with the emerging role of various DNA repair proteins and the regulatory elements which are implicated in cancer therapy such as DNA cross-linking agents, radiotherapy and bleomycin. The DNA repair genes discussed include those involved in BRCA/Rad51-related homologous recombinational repair, DNA-PK related nonhomologous endjoining and the nucleotide excision repair gene, ERCC1. Moreover, the role of regulatory genes such as PARP, ATR, telomerase, growth factor receptors and downstream kinase signalling is examined.
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Titolo: Advances in DNA Repair in Cancer Therapy
Autori: Panasci - Aloyz - Alaoui Jamali
Editore: Springer Verlag
Collana: Cancer Drug Discovery and Development
Finitura: Copertina rigida