The term Vitamin D designates a group of closely related seco-steroids with antirachitic activity. The two most important members of these are ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3). About 80% of the vitamin D supply in man is produced in the skin and only 20% is provided by nutrition.The first analogue of Vitamin D, dihydrotachysterol, was developed in the 1930s and used in the treatment of primary or secondary hypoparathyroidism. It then took 40 years to learn that Vitamin D was not the biologically active principle for healing bone disease. It has to be hydroxylated in the liver at position 25 to build 25-hydroxycholecalciferol and then finally in the kidney at position 1a to become 1a,25-dihydroxycholecalciferol [= 1a,25-(OH)2-D3].
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Titolo: Alfacalcidol in Prevention and Treatment of all Major Forms of Osteoporosis and in Renal Osteopathy - Distinction to Plain Vitamin D, Clinical Evidence and Practical Recommendations
Finitura: Copertina flessibile
Misure: 12x19 cm