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The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes: Volume IV : Molecular Genetic and Genomic Markers

di Ritsner  • 2009  • dettagli prodotto

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Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer's disease, epilepsy, alcoholism, substance abuse and others are one of the most debilitating illnesses worldwide characterizing by the complexity of the causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunity to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances into meaningful diagnostic and therapeutic advances. This book offers a broad synthesis of the current knowledge about diverse topics of the biomarker and endophenotype strategies in neuropsychiatry.Table of contents ForewordContributors1. Pharmacogenomic biomarkers in neuropsychiatry: the path to personalized medicine in mental disorders. Ramón Cacabelos2. Pharmacogenetics in neurological diseases. Chantal Depondt3. Gene expression changes and potential impact of endophenotypes in major psychiatric disorders. Gursharan Chana, Janet Kwok, Stephen J. Glatt, Ian P. Everall and Ming T. Tsuang4. Molecular genetics of schizophrenia: focus on symptom dimensions. Michael S. Ritsner and Ehud Susser5. Genetics of mood disorders. Laura Mandelli, Alessandra Nivoli, Alessandro Serretti6. Endophenotype strategy in epilepsy genetics. Dalila Pinto, Dorothée Kasteleijn- Nolst Trenité, Dick Lindhout7. Epilepsy, biomarkers, and genes. Danielle M. Andrade8. Molecular and imaging genetic markers in panic disorder. Katharina Domschke and Juergen Deckert9. The genetics of obsessive-compulsive disorder. Marco A. Grados and Rebecca Dang10. Development of biomarkers for alcoholism and polysubstance abuse. Hiroki Ishiguro, Minori Koga, Yasue Horiuchi, Emmanuel S. Onaivi, Susumu Higuchi11. Role of members of the Nur (NR4A) transcription factors in dopamine-related neurodegenerative and neuropsychiatric disorders. Daniel Lévesque, and Claude RouillardAfterword by Robert H. BelmakerContents of Volumes 1, 2, and 3Contributors of Volumes 1, 2, and 3Index


ISBN: 904812297X

Titolo: The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes: Volume IV : Molecular Genetic and Genomic Markers


Editore: Springer Verlag

Volume: Quarto

Edizione: 2009

Lingua: Inglese

Finitura: Copertina rigida