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copertina di Genome Stability and Human Diseases

Genome Stability and Human Diseases

di Nasheuer  • 2010  • dettagli prodotto

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DESCRIZIONE

Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting ‘bottlenecks’ in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations

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ISBN: 9048134706

Titolo: Genome Stability and Human Diseases

Autori:

Editore: Springer Verlag

Volume: Unico

Edizione: 2010

Lingua: Inglese

Finitura: Copertina rigida

Pagine: 390