Basic Clinical Pharmacokinetics

di Winter • 2009 • dettagli prodotto

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DESCRIZIONE

Basic Clinical Pharmacokinetics was designed to simplify pharmacokinetics to help busy practitioners and pharmacy students in clinical settings understand and visualize basic principles. An easy-to-read, case-study format has made the text a favorite among students, clinical professors, and practitioners. Part 1 provides a basic review of pharmacokinetic principles, with extensive explanations, graphic illustrations, and detailed algorithms. Part 2 explains the clinical applications of these principles to problems commonly encountered in the practice setting with specific drugs. This edition includes the latest information on the clinical use of serum drug concentrations. New case studies and examples demonstrate the application of pharmacokinetics in today's clinical practicePart 1 provides a basic review of pharmacokinetic principles, with extensive explanations, graphic illustrations, and detailed algorithms. Part 2 explains the clinical applications of these principles to problems commonly encountered in the practice setting with specific drugs. This edition includes the latest information on the clinical use of serum drug concentrations. New case studies and examples demonstrate the application of pharmacokinetics in today's clinical practice.Table Of Contents Part I: BASIC PRINCIPLESBioavailability Administrative Rate Desired Plasma Concentration Volume of Distribution Clearance Elimination Rate Constant(K) and Half-Life (t1/2) Maximum and Minimum Plasma Concentrations Selecting the Appropriate Equation Interpretation of Plasma Drug Concentrations Creatinine Clearance Dialysis of DrugsPart II: DRUG MONOGRAPHS1. Aminoglycoside Antibiotics 2. Carbamazepine 3. Digoxin 4. Ethosuximide 5. Immunosuppressants: Cyclosporine, Tacrolimus and Sirolimus 6. Lidocaine 7. Lithium 8. Methotrexate (MTX) 9. Phenobarbital 10. Phenytoin 11. Theophylline 12. Valproic Acid 13. Vancomycin