This book is the result of the efforts of the speakers and chairmen of the past two EuroSIVA meetings held in Barcelona and Amsterdam in 1998 and 1999, respectively. The manuscripts, brought together in this book, give an overview of the presentations at these meetings and thereby offer an insight into the state of the art of intravenous anaesthesia science and the application of scientific data to clinical practice. The book is divided into four sections, on the modelling of anaesthetic action with special interest in the effect site, the perioperative use of intravenous hypnotic agents, the state of the art of neuromuscular blockade, and, lastly, on opioids as used for perioperative pain relief. We hope that this book reflects the same atmosphere of scientific progress and collaboration in intravenous anaesthetic drug pharmacology that was experienced in the Barcelona and Amsterdam meetings. Furthermore we are sure that it will be of educational value to all of us, anaesthesiologists and pharmacologists, who are involved in the science and clinical application of anaesthesia. Table of contents List of contributors. Preface. Modelling of anaesthetic action: The effect site. Physiological modelling and the effect site; M. Weiss. Targeting the effect site; J.G. Bovill. Effect sites of intravenous anaesthetic agents; K. Morita, et al. Exploring the plasma-effect site concentration difference during effect site controlled infusion; C. Moiny, et al. Genetic models and mapping genes in the study of anaesthetic action; V.J. Simpson, et al. The perioperative use of hypnotic agents. Total intravenous anaesthesia: the equipment; F.H.M. Engbers. Closed loop control of general anaesthesia; A. Absolom, G.N.C. Kenny. The effect of opioids on the pharmacokinetics and pharmacodynamics of propofol; J. Vuyk. Strategies to prevent awareness; M. Struys, et al. Patient controlled sedation during locoregional anaesthesia; N. Sutcliffe, D. Amutike. Target controlled sedation in the intensive care unit; S.M. Groen-Mulder. State of the art on neuromuscular blockade. Computer-controlled infusion of neuromuscular blocking agents; V. Billard, P. Mavoungou. New neuromuscular blocking agents and fast-tracking anaesthesia; H. Mellinghoff. Neuromuscular blocking agents in the elderly; F. Servin. The use of neuromuscular blocking agents in the ICU; K.S. Khünl-Brady. Neuromuscular blocking agents and neuromuscular diseases; B. Plaud, F. Donati. Sites of respiratory action of opioids; E. Sarton, A. Dahan. Remifentanil - a new age in anaesthesia? J. Raeder. Monitored anaesthesia care with remifentanil; J.R. Sneyd, A. Craig. Remifentanil anaesthesia and postoperative pain management; S. Schraag. Target controlled infusion for postoperative analgesia; M.C.O. van den Nieuwenhuyzen. Serotonin: its implications in postoperative nausea and vomiting; A. Borgeat.
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Titolo: On the Study and Practice of Intravenous Anaesthesia
Autori: Vuyk - Engbers - Frank - Groen Mulder - Sandra
Editore: Springer Verlag
Finitura: Copertina rigida
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