Angiogenesis Inhibition

di Berdel - Kessler - Liersch • 2009 • dettagli prodotto

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DESCRIZIONE

Introduction. Angiopoietins.- HIF-1a and cancer therapy.- Chemokines.- Platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) and their receptors: biological functions and role in malignancy.- Vascular integrins: therapeutic and imaging targets of tumor angiogenesis. PDGF and vessel maturation.- Lymphangiogenesis in cancer: current perspectives.- Therapeutic compounds in clinical studies of Phase III trials and beyond.- Metronomic chemotherapy -- principles and lessons learned from applications in the treatment of metastatic prostate cancer.- Targeting inflammatory cells to improve anti-VEGF therapies in oncology.- Antibody-based vascular tumor targeting. Caveolae and cancer.