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copertina di Tumor Metabolome Targeting and Drug Development

Tumor Metabolome Targeting and Drug Development

di Kanner  • 2014  • dettagli prodotto

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DESCRIZIONE

The metabolic network in cells promotes the generation of both energy and biomass needed for them to grow, divide and differentiate. However, the metabolism of malignant cells generally varies from that of normal cells. These differences provide a platform for the discovery of new approaches to targeting potential vulnerabilities in cancer cells for therapeutic options Some of the significant changes that occur involve ATP production and consumption that modulates the ATP to ADP ratio, hypoxia and the effects of reactive oxygen species on glycolysis, regulation of mitochondrial respiration, induction and suppression of autophagy, and the Warburg effect and “reverse” Warburg effect--these topics and more are discussed in this volume.

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ISBN: 9781461495444

Titolo: Tumor Metabolome Targeting and Drug Development

Autori:

Editore: Springer Verlag

Volume: Unico

Edizione: 2014

Collana: Cancer Drug Discovery and Development

Lingua: Inglese

Finitura: Copertina rigida

Pagine: 198