This book seeks to describe the different applications of systems and network biology in the pancreatic cancer field. It touches upon numerous topics including applications of computational principles. It begins by considering the use of network and systems biology to understand the origins of pancreatic cancer, including computational tools and discussion of related pathways, oncogene cross-talk, biomarker networks and disease metabolomics. It continues by analysing the use of computational tools to investigate pancreatic cancer progression, maintenance and angiogenesis. Special emphasis is given to systems and network evaluations of the dynamic angiogenesis networks that are the underlying factors in tumor aggressiveness and metastases. Another major area that is cementing its position in cancer research involves non-coding RNA or microRNAs. Computational models have also been applied to understand microRNAs biogenesis, regulation and their role in pancreatic cancer resistance. Addressing this important area, the work provides insights into important network evaluation methodologies related to pancreatic cancer related microRNAs targetome. Critical aspects of mRNA-microRNAs interactions in the light of networks will be presented that are predicted to help prioritize druggable microRNAs in a patient specific manner, and the evolving yet controversial field of pancreatic cancer stems cells. The work concludes by discussing the applications of network sciences in pancreatic cancer drug discovery and clinical trial design.
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Titolo: Molecular Diagnostics and Treatment of Pancreatic Cancer - Systems and Network Biology Approaches
Editore: Elsevier - Academic Press
Finitura: Copertina rigida
Misure: 15x23 cm