Drug Discovery - From Bedside to Wall Street

di Bartfai - Lees • 2006 • dettagli prodotto

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DESCRIZIONE

Everyone expects something from the drug industry. Physicians and patients, investors, regulators and administrators all have an active interest. Everyone wants to know what makes drugs ‘work’ medically and economically. Why are drugs so expensive? Is it the drug companies or investors who demand high profits? What governs the pharmacoeconomics? Why are so few diseases treatable? This book opens the windows and doors of the industry telling the story of drug development by using real stories from inside the process. ContentsProposed Contents: 1. The Art of Putting a Molecule Into Man 2. Raising and Rising Expectations 3. History is good to know 4. The "Better Betablocker Barrier" 5. Why Some Good Drugs Do Not Get a Chance and Why 6. About the Economics of Target and Clinical Candidate Selection 7. Target Based Drug Discovery: Part I 8. Changes Need to be Made 9. Target Based Drug Discovery, Part II 10. "Drugable" Targets 11. So Many Drugs, So Few Entities 12. How to Find a Candidate 13. Practicalities: The Hoops & Hurdles of Big Pharma 14. Practical Trials for a Balanced Portfolio 15. How to Improve the Odds of Finding a Safe Drug that Works 16. The Tribulations of Clinical Trials 17. Linking Putative Targets to Disease States 18. More Ways to Look for Targets 19. The Business Basics 20. Adding Value in a Growth of Industry 21. What's the Most Profitable Approach? 22. Pharmacoeconomics for Biotech 23. Shrinking Value of Targets 24. Assessing Company Assets? Look in the Library 25. To Merge or Not to Merge? 26. Working with the Food and Drug Administration (FDA) 27. Regulating Regulatory Regimens Reliably 28. The Hypothesis Is: There is a Better Way 29. What are "We" all Working on? 30. More Tablets Taken per Day than Meals Served