Drug Resistance in Cancer - Mechanisms and Models

di Goldie - Coldman • 1998 • dettagli prodotto

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DESCRIZIONE

Provides an accessible yet sophisticated account of the mechanisms responsible for drug resistance in cancer. In addition, the authors use clearly explained mathematical models to provide an insight into tumour development and the effectiveness and limitations of drug treatment.Table of Contents Preface1. The biological basis of cancer and the problem of drug resistance2. Tumour growth, stem cells and experimental chemotherapy3. Molecular aspects of drug resistance4. Quantitative descriptions of the origins of drug resistance5. Development and exploration of the random mutation model for drug resistance6. Extensions of the random mutation model for drug resistance7. Clinical predictions of the random mutation model8. Directed versus random mutation and the problem of intrinsic resistance9. Some final thoughts on the problem of drug resistanceIndex