This major new edition fulfils the need for a single-volume, up-to-date information resource on the etiology, pathogenesis, diagnosis and treatment of diseases of skeletal muscles, including the muscular dystrophies, mitochondrial myopathies, metabolic myopathies, ion channel disorders, and dysimmune myopathies. As background to the clinical coverage, relevant information on advances in molecular and developmental biology, immunopathology, mitochondrial biology, ion-channel dynamics, cell membrane and signal transduction science, and imaging technology is summarized. Combining essential new knowledge with the fundamentals of history-taking and clinical examination, this extensively illustrated book will continue to be the mainstay for practising physicians and biomedical scientists concerned with muscle disease. Regular updates on the clinical and basic science aspects of muscle disease - written mainly by rising stars of myology - will be published on an accompanying website.Table of Contents PrefaceForeword John WaltonPart I. The Scientific Basis of Muscle Disease: 1. Structure and function of muscle fibres and motor units Mary Kay Floeter2. Myogenic precursor cells Miranda D. Grounds and Frederic Relaix3. Biochemical and molecular basis of muscle disease Susan Brown and Cecilia Jimenez-MalleberaPart II. Investigation of Muscle Disease: 4. Electromyography and related techniques Eric Logigian and Emma Ciafaloni5. Histopathology and immunoanalysis of muscle Caroline A. Sewry and Maria J. Molnar6. Ultrastructural study of muscle Anders Oldfors7. Diagnostic imaging of muscle Eugenio Mercuri and Marianne de VisserPart III. Description of Muscle DiseaseSection 1. General Aspects: 8. The clinical assessment and a guide to classification of the myopathies David Hilton-Jones and John T. Kissel9. The principles of molecular therapies for muscle diseases George Karpati and Renald GilbertSection 2. Specific Diseases: 10. Dystrophinopathies Michael Sinnreich11. Muscular dystrophies presenting with proximal muscle weakness Mariz Vainzof and Kate Bushby12. Dystrophies and myopathies of early childhood onset Carsten G. Bönnemann and Enrico Bertini13. Congenital myopathies Carina Wallgren-Pettersson and Nigel G. Laing14. Muscle diseases with prominent muscle contractures Gisèle Bonne and Anne K. Lampe15. Facioscapulohumeral muscular dystrophy Shannon L. Venance and Rabi Tawil16. Distal myopathies Bjarne Udd17. Oculopharyngeal muscular dystrophy Bernard Brais18. Myotonic dystrophy John Day and Charles Thornton19. Mitochondrial myopathies and related disorders Patrick F. Chinnery and Eric A. Shoubridge20. Metabolic myopathies John Vissing, Stefano DiDonato and Franco Taroni21. Muscle ion channelopathies and related disorders Bertrand Fontaine and Michael G. Hanna22. Inflammatory and dysimmune myopathies Marinos C. Dalakas and George Karpati23. Myasthenia gravis and myasthenic syndromes [autoimmune and genetic] Amelia Evoli, Hanns Lochmüller and Violeta Mihaylova24. Endocrine and toxic myopathies Zohar Argov and Frank L. Mastaglia25. Myofibrillar myopathy Duygu Selcen26. Hereditary inclusion body myopathies Zohar Argov and Stella Mitrani-Rosenbaum27. Other myopathies Giovanni Meola and Michael Swash.
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Titolo: Disorders of Voluntary Muscle
Autori: Karpati - Hilton Jones - Griggs
Editore: Cambridge University Press
Edizione: VIII 2010
Finitura: Copertina rigida
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